Shire Heritage in Haemophilia
The Shire Pipeline

Shire has been a healthcare leader for more than 60 years, with a rich history of medical "firsts" in the haemophilia community.

A JOURNEY OF ACHIEVEMENTS

First system for separating plasma from whole blood and storing1

1941

First system for separating plasma from whole blood and storing1

1941

Commercially produced factor VIII concentrate1

1968

Therapy for people with haemophilia and antibodies3

1977

Inclusion of heat
treatment in the manufacture of
factor VIII1

1983

Purification of factor VIII by chemical and monoclonal techniques1

1988

Production of factor VIII
by recombinant
technology1

1992

Recombinant production of factor VIII without addition of human or animal proteins1

2003

SHIRE'S QUEST FOR TOMORROW

PIPELINE

Pegylated Recombinant Factor VIII

Haemophilia A

Recombinant von Willebrand Factor

von Willebrand disease

Factor IX Gene-Therapy-Based Treatment

Haemophilia B

Polysialylation recombinant FVIII

Haemophilia A

Inhibitor Management with Bypassing Agents (Recombinant Factor VIIa)

Inhibitor Management

Factor VIII Gene-Therapy-Based Treatment

Haemophilia A
Timeline of Shire's product pipeline is for illustrative purposes only; exact approval dates are unknown and subject to regulatory decisions.
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